...

Research Training Group “Medicinal Chemistry of Selective GPCR Ligands” (GRK 1910)

Besøk nettside

Om arbeidsgiveren

Topic and Aims of the Research Training Group

Approximately 30 % of the drugs on the market exert their biological activities upon binding to G-protein coupled receptors (GPCRs). As biological targets, GPCRs are associated with exceptional progress in the field of drug research, enabling the application of molecular strategies for the discovery of innovative therapeutic principles. Severe diseases are frequently associated with dysfunctions of GPCRs. The biological activity of GPCR agonists and antagonists is determined by multidimensional selectivity profiles, resulting in both desired and adverse effects. Besides receptor subtype selectivity, this includes functional selectivity (biased signaling), selectivity for receptor conformations, receptor dimers, allosteric receptor sites, orthologs and mutants.

The proposed Research Training Group aims to explore the ligand induced control of monoaminergic and peptidergic GPCRs at aforementioned levels of selectivity. In addition to the elucidation of molecular mechanisms, we attempt to contribute to a rational development of functionally selective GPCR drugs for the treatment of chronic inflammatory, cardiovascular and CNS diseases and for diagnostic purposes. The research programme is strongly interdisciplinary, covering computer assisted design of selective ligands and molecular tools with the aid of GPCR models, chemical synthesis of target compounds, novel concepts of bioisosteric replacement, the investigation of ligand-receptor interactions and the elaboration of functional selectivity by analysis of ligand-specific signaling including the development of appropriate assays.

The programme specific interdisciplinary qualification profile integrates chemical, radiopharmaceutical, pharmacological, molecular biological, bioanalytical and biochemical aspects of drug research as well as methods of modern drug discovery. The main issues of the qualification programmes for graduates and postdoctoral associates in the Research Training Group are retreats, workshops and seminar/webinar days, dealing with and promoting the core research idea. Furthermore, within their projects all graduates will get the opportunity to work for 3-4 months in the research labora-tory of a collaborator abroad to acquire new knowledge, apply modern methods and techniques and to gain international experience even before the completion of the doctorate.


FAU Erlangen-Nürnberg 
Schuhstr. 19 
D-91052 Erlangen

 

Universität Regensburg                                                                 
Universitätsstr. 31 
D-93053 Regensburg 

 

   

Arbeidsgivers plassering

Oppdag lignende arbeidsgivere

...
KTH Royal Institute of Technology Stockholm, Sverige 115 åpne stillinger
...
University of Luxembourg Luxembourg 103 åpne stillinger
...
KU Leuven Leuven, Belgia 91 åpne stillinger
...
Ghent University Gent, Belgia 69 åpne stillinger
...
ETH Zürich Zürich, Switzerland 61 åpne stillinger
Flere arbeidsgivere

Interessante artikler

...
5 Reasons to Pursue Your PhD at EMBL European Molecular Biology Laboratory (EMBL) 4 min lesning
...
Deciphering the Gut’s Clues to Our Health University of Turku 5 min lesning
...
Understanding Users to Optimise 3D Experiences Centrum Wiskunde & Informatica (CWI) 5 min lesning
...
Harnessing the Rhizosphere to Protect Our Soil Free University of Bozen - Bolzano 5 min lesning
Flere stories