Laboratory Technician: Therapeutic Discovery in Childhood Cancers (m/f/d)

We are looking for a highly motivated laboratory technician who is excited to work within an international consortium on the identification and development of novel therapeutic strategies for the treatment of childhood cancers.

Your profile 

We are seeking enthusiastic and energetic candidates to join our team. The successful applicant should have a Master’s degree in life sciences and an excellent background in molecular biology or biochemistry. Candidates that have a PhD degree will also be considered. Prior experience in a wet-lab setting is an advantage. The working language at CeMM is English, and excellent written and oral communication skills as well as high accuracy, reliability and excellent interpersonal and organizational skills are a requirement.

Typical tasks

Tasks and responsibilities contain, but are not limited to:

• Cell Culture (maintenance, manipulation via genome engineering)
• High throughput drug screens using our automated facility
• Functional genomics including CRISPR/Cas9 screens and protein stability reporter screens
• General molecular biology techniques (immunoblots, cloning, immunoprecipitations)
• Technology development
• Training of new lab members
• Certain lab management responsibilities

The Winter Lab 

We are an international and multi-disciplinary research lab. When you work with us, you will work in a team of molecular biologists, biochemists, and medicinal chemists. Through our international consortium, we also have access to medical doctors, clinical trial specialists and patient advocates. Our mission is to connect that wide umbrella of backgrounds to reimagine the treatment of solid tumors in children by finding drugs that induce the degradation of well-known drivers of these diseases. You’d be working with high-throughput technologies such as genome-wide CRISPR/Cas9 screens, phenotypic drug screen and proteomics. The setup in our group and in our consortium is interdisciplinary, diverse, and inclusive. This fosters an environment that is required for the generation of innovate ideas and novel concepts that are needed to advance novel therapeutic strategies.

The Principal Investigator 

Georg Winter obtained his PhD from the Medical University of Vienna, working on elucidating the mechanism of action of anti-neoplastic drugs under the supervision of Professor Giulio Superti-Furga at CeMM. He specialized in proteomics as well as chemical genetic approaches to identifying drug resistance mechanisms and on mechanistically elucidating synergistic drug combinations. He continued his training in chemical biology, working as a postdoctoral fellow with Dr. James Bradner at the Dana Farber Cancer Institute/Harvard Medical School. There, he innovated a generalizable pharmacological solution to in vivo target protein degradation and applied this strategy to the study of leukemic gene regulation. Georg Winter was recruited as CeMM principal investigator in June 2016. His lab develops and applies methods for target protein degradation with the ultimate goal of understanding and disrupting oncogenic transcriptional circuits. To that end, the Winter laboratory combines phenotypic drug screens, chemical genetics, and drug-target identification approaches with holistic measurements of global gene activity and genome structure. The ultimate goal of the research conducted in the Winter laboratory is to connect basic research in gene regulation and the ubiquitin proteasome system with functional genomics and chemical probe development to develop novel and personalized therapeutic paradigms.

About the Institute

CeMM is an international research institute of the Austrian Academy of Sciences and a founding member of EU-LIFE. The mission of CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences is to achieve maximum scientific innovation in molecular medicine to improve healthcare. At CeMM, an international and creative team of scientists and medical doctors pursues free-minded basic life science research in a large and vibrant hospital environment of outstanding medical tradition and practice. At CeMM, an international and creative team of scientists and medical doctors pursues free-minded basic life science research in a large and vibrant hospital environment of outstanding medical tradition and practice. CeMM’s research is based on post-genomic technologies and focuses on societally important diseases, such as immune disorders and infections, cancer, aging and metabolic disorders. CeMM operates in a unique mode of super-cooperation, connecting biology with medicine, experiments with computation, discovery with translation, and science with society and the arts. CeMM discovers and develops technologies to explore human biology with the purpose of defeating disease at its roots. Because Science is our Medicine! CeMM trains a modern blend of biomedical scientists and is located at the campus of the General Hospital and the Medical University of Vienna. CeMM is a proud recipient of the HR Excellence in Research Award (HRS4R). This award indicates that CeMM takes care of the well-being of its employees, that the recruitment process is open, fair, and transparent, and that CeMM offers professional appraisals and career development procedures.   More than 150 people from 49 nationalities are working at CeMM. The institute promotes equal opportunity and harbours a mix of different talents, backgrounds, competences, and interests. www.cemm.at

We offer

• Work within an experienced, interdisciplinary, and international team at one of Austria’s leading research institutes
• Ample opportunities to contribute and gain experience in a key area of biomedical research and precision medicine
• An inspiring workplace with an international setting, strong team spirit, and an excellent work climate
• A wide range of social, cultural, and sports activities organized by the institute
• Excellent employee benefits including full insurance coverage (health, accident, retirement), health care services, subsidized cafeteria
• Minimum monthly gross salary of EUR 2.850,00 paid out 14 times yearly (following the recommendations of FWF). 
• Support for relocating to Vienna is provided (relocation reimbursement, visa support, etc.) 

Your application 

Please apply online (https://cemm.onlyfy.jobs/job/x7ekv0z2) 

Interested candidates are encouraged to upload their application documents (including a cover letter, a CV and names and contact details of at least 2 referees) online. Applications will be reviewed on a rolling basis until end of April 2024.

Additional information

City Vienna

Position type Full-time employee

Start of work 01.06.2024

Responsible

Memo Mokhles